Title :
Effects of Acute Hippocampal Stimulation on EEG Dynamics
Author :
Nair, Sandeep P. ; Sackellares, J. Chris ; Shiau, Deng-Shan ; Norman, Wendy M. ; Dance, Linda K. ; Pardalos, Panos M. ; Principe, Jose C. ; Carney, Paul R.
Author_Institution :
Dept. of Biomed. Eng., Florida Univ., Gainesville, FL
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus in humans. We postulate that this anticonvulsant effect is due to dynamical resetting by the electrical stimulation. The following study investigated the effects of acute hippocampal electrical stimulation on dynamical transitions in the brain of a spontaneously seizing animal model of TLE to test the hypothesis of divergence in dynamical values by electrical stimulation of the hippocampus
Keywords :
bioelectric phenomena; diseases; electroencephalography; neurophysiology; EEG dynamics; acute hippocampal electrical stimulation; anticonvulsant effects; brain region; high frequency stimulation; human temporal lobe epilepsy; postictal dynamical divergence; preictal dynamical convergence; Brain modeling; Convergence; Electrical stimulation; Electroencephalography; Epilepsy; Frequency; Hippocampus; Humans; Rodents; Temporal lobe;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.260830
