DocumentCode :
473678
Title :
Activity index from continuous telemetry in a mouse model of voluntary wheel exercise training
Author :
McSharry, P.E. ; Adlam, D. ; de Bono, J.P. ; Channon, K.M.
Author_Institution :
Dept. of Eng. Sci., Univ. of Oxford, Oxford
fYear :
2006
fDate :
17-20 Sept. 2006
Firstpage :
89
Lastpage :
92
Abstract :
Mouse models are now widely used for studying gene function and facilitating drug discovery and development within the pharmaceutical industry. The availability of murine biomedical signals brings new challenges in terms of obtaining recordings, signal processing and analysis. Heart rate variability (HRV) is predictive of prognosis in cardiovascular disease states, especially heart failure, and also provides a measure of autonomic function. Reliable estimation of HRV metrics are of interest to those carrying out biomedical research with mouse models. A voluntary murine wheel running model is employed to test how HRV is mediated by the autonomic nervous system. Telemeters are used to measure the blood pressure waveform at 500 Hz in freely moving mice, providing a time series of cardiac interbeat intervals. An activity index is derived from the heart rate signal and compared with an independent measure of three activity states: (i) rest; (ii) activity; and (Hi) exercise.
Keywords :
biomedical telemetry; cardiovascular system; drugs; haemodynamics; medical signal processing; activity index; autonomic nervous system; blood pressure waveform; cardiovascular disease states; continuous telemetry; drug discovery; frequency 500 Hz; gene function; heart failure; heart rate variability; mouse model; murine biomedical signals; telemeters; voluntary murine wheel running model; voluntary wheel exercise training; Availability; Biomedical measurements; Drugs; Heart rate variability; Industrial training; Mice; Pharmaceuticals; Signal processing; Telemetry; Wheels;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computers in Cardiology, 2006
Conference_Location :
Valencia
Print_ISBN :
978-1-4244-2532-7
Type :
conf
Filename :
4511795
Link To Document :
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