DocumentCode :
473845
Title :
Contribution of electrophysiological remodelling to generation of anatomical re-entries around the right pulmonary veins in human atrium: a simulation study
Author :
Tobón, C. ; Sáiz, J. ; Hornero, F. ; Ruiz, C. ; Hernández, V. ; Molto, G.
Author_Institution :
Center for Res. & Innovation on Bioeng., Polytech. Univ. of Valencia, Valencia
fYear :
2006
fDate :
17-20 Sept. 2006
Firstpage :
773
Lastpage :
776
Abstract :
Atrial arrhythmias are characterised by rapid and irregular activation of atrium. In this study, the effects of remodelling on ionic currents were incorporated in a model of human atrial action potential and were integrated in a two-dimensional (2D) model of human left atrium tissue including orifices for right pulmonary veins. We examined the effects of atrial remodelling on atrial arrhythmias when ectopic beats between pulmonary veins were applied. Under normal tissue conditions, no re-entry phenomenon was induced. In atrial remodelling, action potential duration (APD), effective refractory period (ERP) and conduction velocity (CV) were decremented and stable re-entries around the right pulmonary veins were produced. Our study suggests that the electrical remodelling is a key factor to generate anatomical re-entries around the pulmonary veins.
Keywords :
bioelectric phenomena; blood vessels; cardiology; cellular biophysics; 2D human left atrium model; APD; CV; ERP; action potential duration; anatomical reentry generation; atrial activation; atrial arrhythmia; conduction velocity; ectopic beats; effective refractory period; electrophysiological remodelling; human atrial action potential model; human atrium; ionic currents; reentry phenomenon; right pulmonary vein; Animals; Biomedical engineering; Computational modeling; Conductivity; Humans; Indium tin oxide; Kinetic theory; Orifices; Technological innovation; Veins;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computers in Cardiology, 2006
Conference_Location :
Valencia
Print_ISBN :
978-1-4244-2532-7
Type :
conf
Filename :
4511966
Link To Document :
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