Detection of tulobuterol crystal in transdermal tapes using terahertz pulsed spectroscopy and imaging

Author

Sakamoto, Tomoaki ; Portieri, Alessia ; Taday, Philip F. ; Sasakura, Daisuke ; Terahara, Takaaki ; Miura, Tsuyoshi ; Higo, Naruhito ; Arnone, Donald D. ; Hiyama, Yukio

Author_Institution

Div. of Drugs, Nat. Inst. of Health Sci., Tokyo

fYear

2007

fDate

2-9 Sept. 2007

Firstpage

569

Lastpage

570

Abstract

Applicability of the terahertz pulsed spectroscopy (TPS) and the terahertz pulsed imaging (TPI) to detect tulobuterol (TBR) crystal in transdermal tape has been investigated. The TBR crystal was identified by comparison between spectrum of tapes and TBR reference standard. The TBR crystal in patch matrix was successfully detected by the TPS and TPI. These results indicate that the TPS and TPI are applicable to identify an active substance in patch matrix for quality control.

Keywords

patient diagnosis; skin; submillimetre wave imaging; submillimetre wave spectroscopy; patch matrix; quality control; terahertz pulsed imaging; terahertz pulsed spectroscopy; transdermal tapes; tulobuterol crystal detection; Chemical technology; Crystals; Optical imaging; Optical pulses; Pharmaceutical technology; Pulse measurements; Spatial resolution; Spectroscopy; Thickness measurement; Time measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared and Millimeter Waves, 2007 and the 2007 15th International Conference on Terahertz Electronics. IRMMW-THz. Joint 32nd International Conference on

Conference_Location

Cardiff

Print_ISBN

978-1-4244-1438-3

Type

conf

DOI

10.1109/ICIMW.2007.4516633

Filename

4516633