Notice of RetractionStudy of the Plasma Metabolic Phenotype in Rats with Chronic Immobilization Stress

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

To determine changes in the plasma metabolic phenotype in rats with chronic immobilization stress (CIS), and attempt to interpretation of metabonomic changes in the rats induced by CIS via determination of characteristic metabolic products and discovery of biomarkers in the rats. Blood was collected from the cardioventricle under anesthesia and detected by using the Fourier variable superconducting nuclear magnetic resonance (NMR) spectrometer. The results showed: the PCA analysis of rat plasma ¹H NMR spectra revealed different metabolic spectra between stress and control groups, which was consistent with alterations of in vivo metabolisms in rats under stress stimuli. It can be concluded that: the metabolic phenotype of CIS includes increases in plasma levels of lactic acid, choline, NAC, saturated fatty acid, and decreases in the levels of unsaturated fatty acid, blood sugar, HDL, and the unknown compounds (3.44 ppm). These metabolic components also may be the biomarkers of metabolites induced by CIS.