Title :
Control of Fed-Batch Culture of Hybridoma Cells for Monoclonal Antibody Production
Author :
de Tremblay, Michele ; Perrier, Michel ; Chavarie, Claude ; Archambault, Jean
Author_Institution :
Biotechnology Research Institute, 6100 Royalmount Ave., Montréal, Québec, Canada H4P 2R2; Ecole Polytechnique de Montréal, Department of Chemical Engineering
Abstract :
Control of fed-batch culture of hybridoma cells was investigated from two approaches: optimal control theory and feedback control. Optimal control policy generated a higher concentration of MAb experimentally than the feedback approach for the chosen set-point. In both cases, the viability of the cells is lower than the model predictions.
Keywords :
Amino acids; Animals; Biotechnology; Chemical engineering; Dynamic programming; Feedback control; Feeds; Mass production; Optimal control; Sugar;
Conference_Titel :
American Control Conference, 1990
Conference_Location :
San Diego, CA, USA
