Title :
Probabilistic Model for Biological Networks
Author :
Du, Cai-Feng ; Xiao, Lan ; Ren, Wei
Author_Institution :
Coll. of Math. & Comput. Sci., China Univ. of Pet., Dongying, China
Abstract :
Recently there has been considerable interest in studying biological networks such as gene regulatory networks and protein-protein interaction networks. Are biological networks different from other large complex networks? Both large biological and other networks have power law degree distribution, yet the exponents fall into different ranges. This may be because random elimination of the information in the genome is a dominant evolutionary force in shaping biological networks. In this paper, we give a probabilistic model to examine the evolution of biological networks by random elimination processes of node degree as well as the preferential choice mechanisms. For the model, it is proved that there is a stationary power law degree distribution with exponents less than 2, consist with current data on biological networks.
Keywords :
biology computing; cellular biophysics; genetics; genomics; molecular biophysics; proteins; random processes; statistical distributions; biological networks; complex networks; gene regulatory networks; genome; power law degree distribution; preferential choice mechanisms; probabilistic model; protein-protein interaction networks; random elimination; Bioinformatics; Biological system modeling; Biology computing; Computer networks; Educational institutions; Fungi; Genomics; Mathematical model; Mathematics; Proteins; biological network; degree distribution; preference; random elimination;
Conference_Titel :
Information and Computing Science, 2009. ICIC '09. Second International Conference on
Conference_Location :
Manchester
Print_ISBN :
978-0-7695-3634-7
DOI :
10.1109/ICIC.2009.273