Title :
High-throughput screening of small-molecule microarrays with label-free optical scanning microscope
Author :
Fei, Y.Y. ; Landry, J.P. ; Sun, Y.S. ; Wang, X.B. ; Luo, J.T. ; Lam, K.S. ; Zhu, X.D.
Author_Institution :
Dept. of Phys., Univ. of California at Davis, Davis, CA, USA
Abstract :
We investigated surface chemistry platforms for immobilizing two types of synthetic, small-molecule compound libraries, each with over 6000 compounds, and for screening these compounds for potential proteins ligands by a label-free optical scanning microscope.
Keywords :
biological techniques; molecular biophysics; optical microscopy; proteins; surface chemistry; high-throughput screening; label-free optical scanning microscope; protein ligands; small-molecule compound libraries; small-molecule microarrays; surface chemistry; synthetic compound libraries; Biomedical optical imaging; Chemistry; Fluorescence; Glass; Lenses; Libraries; Mirrors; Optical beams; Optical microscopy; Proteins; 000.1430; 000.1570; 170.0170; 180.0180;
Conference_Titel :
Lasers and Electro-Optics, 2009 and 2009 Conference on Quantum electronics and Laser Science Conference. CLEO/QELS 2009. Conference on
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-55752-869-8
Electronic_ISBN :
978-1-55752-869-8
