Characterization of magnetic nanoparticles functionalized with albumin for biological applications

Author

Draghiciu, L. ; Eftime, L. ; Muller, R. ; Popescu, M. ; Herghelegiu, A. ; Schiopu, V. ; Danila, M.

Author_Institution

Nat. Inst. for R&D in Microtechnol. (IMT Bucharest), Bucharest, Romania

Volume

1

fYear

2009

fDate

12-14 Oct. 2009

Firstpage

167

Lastpage

170

Abstract

In this paper we present a method for the large-scale preparation of biodegradable, biocompatible magnetic nanospheres, intended to be used for cell labeling techniques in magnetic separation of cells. We obtained magnetite nanoparticles functionalized with albumin using an ultrasonic method, at temperatures between 80-95degC. They were tested in a microfluidic channel. The characterization of the the magnetic nanoparticles functionalized with albumin was performed by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) and XRD. Nano-sized-materials such as magnetite functionalized with albumin nanoparticles demonstrated attractive physical-chemical properties that can be exploited to develop new bio-diagnostic and therapeutic strategies as well as novel biotechnology methodologies.

Keywords

Fourier transform spectra; X-ray diffraction; infrared spectra; iron compounds; magnetic particles; nanobiotechnology; nanoparticles; scanning electron microscopy; FTIR; Fe₃O₄; Fourier transform infrared spectroscopy; X-ray diffraction; XRD; albumin functionalised magnetic nanoparticles; albumin functionalised magnetite nanoparticles; biodegradable biocompatible magnetic nanospheres; cell labeling techniques; cellular magnetic separation; nanosized materials; nanosphere preparation; scanning electron microscopy; temperature 80 degC to 95 degC; ultrasonic method; Biodegradable materials; Labeling; Large-scale systems; Magnetic separation; Microfluidics; Nanobioscience; Nanoparticles; Scanning electron microscopy; Temperature; Testing; Biomedical; Magnetite; Microfluidc system; SU-8 polymer; Serum albumin;

fLanguage

English

Publisher

ieee

Conference_Titel

Semiconductor Conference, 2009. CAS 2009. International

Conference_Location

Sinaia

ISSN

1545-827X

Print_ISBN

978-1-4244-4413-7

Type

conf

DOI

10.1109/SMICND.2009.5336582

Filename

5336582