Title :
On manipulation and detection of biomolecules using magnetic carriers
Author :
Volmer, M. ; Avram, M. ; Avram, A.M.
Author_Institution :
Phys. Dept., Transilvania Univ., Brasov, Romania
Abstract :
We performed micromagnetic simulations regarding the detection of magnetic microbeads using spin-valve sensors. Detection of magnetic fields generated by these magnetic particles encapsulated in plastic, carbon or ceramic spheres which are coated with chemical or biological species such as DNA or antibodies that selectively bind to the target analyte can be made using giant magnetoresistive (GMR) or planar Hall effect (PHE) sensors made from spin-valve structures. This detection concept is suitable to biomolecular recognition, and in particular to single molecule detection. The concept and the realization of a magnetohydrodynamic micro pump are presented.
Keywords :
biological techniques; magnetic particles; magnetic sensors; molecular biophysics; nanobiotechnology; spin valves; DNA coating; antibody coating; biomolecular recognition; biomolecule detection; biomolecule manipulation; carbon sphere; ceramic sphere; encapsulated magnetic particles; giant magnetoresistive sensors; magnetic carriers; magnetic field detection; magnetic microbead detection; magnetohydrodynamic micropump; micromagnetic simulations; planar Hall effect sensors; plastic sphere; single molecule detection; spin valve sensors; Biological system modeling; Biosensors; Ceramics; Chemical and biological sensors; Giant magnetoresistance; Magnetic particles; Magnetic sensors; Micromagnetics; Molecular biophysics; Plastics; Biomedical application; Lab-on-chip; Magnetic nanoparticles; Magnetoresistive sensors; Micromagnetic simulations;
Conference_Titel :
Semiconductor Conference, 2009. CAS 2009. International
Conference_Location :
Sinaia
Print_ISBN :
978-1-4244-4413-7
DOI :
10.1109/SMICND.2009.5336583
