Similarity Analysis of DNA Sequences Using “Molecular Connectivity Indices” Method

According to ¿molecular connectivity indices¿ method, four parameters basing on the locations and occurrence frequencies of four bases (A, C, G, T) in DNA sequences were extracted to characterize the DNA sequences of different species. Similarity analysis among several species was performed basing on Euclidean distance and phylogenetic tree. The results showed that the computation results are in agreement with the phylogenetic tree and conform to the evolutionary rules. The method is valuable in the homology study of species and it also may be applied in other fields of bioinformatics.