Surface plasma resonance optical analysis for multi- channel refractive index monitoring

This paper presents a multi-angle optical analysis device based on surface plasmon resonance (SPR) for simultaneous biological sample detection. Most applications of optical SPR devices were designed to measure refractive index (RI) of liquid or gas sample by measuring the signal wavelength or single angle, the sensitivity and stability of which is easily affected by the fluctuation of various interior or exterior test conditions. In this study, we have proposed a multi-channel optical SPR device which can monitor SPR changes in different wavelengths and angles. The preliminary experimental results demonstrate the characteristic responses of SPR signals from different angles changes independently correspond to the refraction index changes of the liquid samples with which they are in contact. The experimental results confirmed that a practicable high-sensitivity multi-channel SPR biological measurement instrument could be completed with further developments.