Title :
Alterations of the ECM in ovarian carcinogenesis studied by second harmonic Generation imaging microscopy
Author :
Nadiarnykh, Oleg ; LaComb, Ronald B. ; Brewer, Molly A. ; Campagnola, Paul J.
Author_Institution :
University of Connecticut Health Center, Center for Cell Analysis and Modeling, Department of Cell Biology, Farmington, CT 06030, USA
Abstract :
We have used Second Harmonic Generation (SHG) imaging microscopy to quantify alterations in the fibrillar collagen assembly in ex vivo human malignant and normal ovarian tissues. We integrate 3D imaging measurements, bulk optical parameter measurements, and Monte Carlo simulations to isolate the structural factors that are different in these tissues.
Keywords :
Assembly; Cancer; Electrochemical machining; Frequency conversion; Humans; Integrated optics; Microscopy; Nonlinear optics; Optical harmonic generation; Optical imaging;
Conference_Titel :
Communications and Photonics Conference and Exhibition (ACP), 2009 Asia
Conference_Location :
Shanghai, China
Print_ISBN :
978-1-55752-877-3
Electronic_ISBN :
978-1-55752-877-3
