pH-triggered release of paclitaxel from nanoengineered polymeric capsules

Author

Pastorino, Laura ; Soumetz, Federico Caneva ; Ruggiero, Carmelina ; Erokhina, Svetlana

Author_Institution

Dept. of Commun., Comput. & Syst., Sci., Univ. of Genova, Genova, Italy

fYear

2009

fDate

26-30 July 2009

Firstpage

133

Lastpage

135

Abstract

Paclitaxel is an anticancer agent often used in clinical oncology practice. Polymeric capsules represent an effective tool for the encapsulation and smart release of different compounds. Paclitaxel was loaded into the capsules, fabricated by means of the layer-by-layer assembly of oppositely charged polyelectrolytes. The effective encapsulation of paclitaxel was demonstrated and its release was characterized. Finally the biological activity of encapsulated paclitaxel against human breast cancer cells was assessed.

Keywords

biochemistry; biological organs; cancer; cellular biophysics; drugs; encapsulation; gynaecology; nanobiotechnology; nanostructured materials; pH; patient treatment; polymer electrolytes; self-assembly; anticancer agent; biological activity; breast cancer cells; chemotherapy; encapsulation; layer-by-layer assembly; nanoengineered polymeric capsules; paclitaxel pH-triggered release; polyelectrolytes; Breast cancer; Cells (biology); Drug delivery; Encapsulation; Fabrication; Humans; Medical treatment; Nanobioscience; Oncology; Polymers; cytotoxicity; paclitaxel; polyelectrolyte self-assembling; polymeric capsules; triggered release;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology, 2009. IEEE-NANO 2009. 9th IEEE Conference on

Conference_Location

Genoa

ISSN

1944-9399

Print_ISBN

978-1-4244-4832-6

Electronic_ISBN

1944-9399

Type

conf

Filename

5394583