Study of biomineralization processes by cryo-TEM

Author

Valentini, F. ; Landi, E. ; Sandri, M. ; Sommerdijk, Nico ; Nudelman, Fabio ; Tampieri, A.

Author_Institution

Inst. of Sci. & Technol. for Ceramics, Nat. Res. Council, Faenza, Italy

fYear

2009

fDate

26-30 July 2009

Firstpage

348

Lastpage

350

Abstract

The present work describes the study of the biomineralization process of biohybrid composite for bone substitution and repair. The material was developed nucleating apatitic phases on self assembling collagen fibers, acting as a template. Using cryogenic transmission microscopy (cryo-TEM) it is possible to freeze material specimens at different times of the mineralization process and then observe the vitrified samples at cryogenic temperature. The preparation procedure of the specimens was set up. The nucleation of the apatitic phase on the collagen was observed from the beginning of the synthesis and the time needed for the complete assembling of the collagen fiber was determined.

Keywords

biomedical materials; biomineralisation; bone; cryogenics; freezing; nucleation; self-assembly; transmission electron microscopy; biohybrid composite; biomineralization processes; bone repair; bone substitution; cryo-TEM; cryogenic transmission microscopy; material specimen freezing; nucleating apatitic phases; self assembling collagen fibers; Active matrix organic light emitting diodes; Biological materials; Bones; Chemical technology; Cryogenics; Crystalline materials; Microscopy; Mineralization; Temperature; Vitrification; Cryo-TEM; apatite-collagen; bio-hybrid material; biomineralization;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology, 2009. IEEE-NANO 2009. 9th IEEE Conference on

Conference_Location

Genoa

ISSN

1944-9399

Print_ISBN

978-1-4244-4832-6

Electronic_ISBN

1944-9399

Type

conf

Filename

5394646