Title :
Study of biomineralization processes by cryo-TEM
Author :
Valentini, F. ; Landi, E. ; Sandri, M. ; Sommerdijk, Nico ; Nudelman, Fabio ; Tampieri, A.
Author_Institution :
Inst. of Sci. & Technol. for Ceramics, Nat. Res. Council, Faenza, Italy
Abstract :
The present work describes the study of the biomineralization process of biohybrid composite for bone substitution and repair. The material was developed nucleating apatitic phases on self assembling collagen fibers, acting as a template. Using cryogenic transmission microscopy (cryo-TEM) it is possible to freeze material specimens at different times of the mineralization process and then observe the vitrified samples at cryogenic temperature. The preparation procedure of the specimens was set up. The nucleation of the apatitic phase on the collagen was observed from the beginning of the synthesis and the time needed for the complete assembling of the collagen fiber was determined.
Keywords :
biomedical materials; biomineralisation; bone; cryogenics; freezing; nucleation; self-assembly; transmission electron microscopy; biohybrid composite; biomineralization processes; bone repair; bone substitution; cryo-TEM; cryogenic transmission microscopy; material specimen freezing; nucleating apatitic phases; self assembling collagen fibers; Active matrix organic light emitting diodes; Biological materials; Bones; Chemical technology; Cryogenics; Crystalline materials; Microscopy; Mineralization; Temperature; Vitrification; Cryo-TEM; apatite-collagen; bio-hybrid material; biomineralization;
Conference_Titel :
Nanotechnology, 2009. IEEE-NANO 2009. 9th IEEE Conference on
Conference_Location :
Genoa
Print_ISBN :
978-1-4244-4832-6
Electronic_ISBN :
1944-9399
