DocumentCode :
51441
Title :
Dynamic Cardiac PET Imaging: Extraction of Time-Activity Curves Using ICA and a Generalized Gaussian Distribution Model
Author :
Mabrouk, R. ; Dubeau, F. ; Bentabet, L.
Author_Institution :
Dept. of Comput. Sci., Univ. de Sherbrooke, Sherbrooke, QC, Canada
Volume :
60
Issue :
1
fYear :
2013
fDate :
Jan. 2013
Firstpage :
63
Lastpage :
71
Abstract :
Kinetic modeling of metabolic and physiologic cardiac processes in small animals requires an input function (IF) and a tissue time-activity curves (TACs). In this paper, we present a mathematical method based on independent component analysis (ICA) to extract the IF and the myocardium´s TACs directly from dynamic positron emission tomography (PET) images. The method assumes a super-Gaussian distribution model for the blood activity, and a sub-Gaussian distribution model for the tissue activity. Our appreach was applied on 22 PET measurement sets of small animals, which were obtained from the three most frequently used cardiac radiotracers, namely: desoxy-fluoro-glucose (18F-FDG), [13 N]-ammonia, and [11C]-acetate. Our study was extended to PET human measurements obtained with the Rubidium-82 (82 Rb) radiotracer. The resolved mathematical IF values compare favorably to those derived from curves extracted from regions of interest (ROI), suggesting that the procedure presents a reliable alternative to serial blood sampling for small-animal cardiac PET studies.
Keywords :
Gaussian distribution; biological tissues; blood; cellular biophysics; image reconstruction; medical image processing; physiological models; positron emission tomography; radioactive tracers; ICA; PET human measurements; [11C]-acetate; [13N]-ammonia; blood activity; cardiac radiotracers; desoxy-fluoro-glucose; dynamic cardiac PET imaging; dynamic positron emission tomography imaging; generalized gaussian distribution model; independent component analysis; input function; kinetic modeling; mathematical IF values; mathematical method; metabolic cardiac processes; myocardiums; physiologic cardiac processes; regions of interest; rubidium-82 radiotracer; serial blood sampling; small-animal cardiac PET; sub-Gaussian distribution model; super-Gaussian distribution model; time-activity curves; tissue activity; tissue time-activity curves; Blood; Covariance matrix; Eigenvalues and eigenfunctions; Equations; Mathematical model; Positron emission tomography; Independent component analysis (ICA); input function (IF); kinetic modeling; positron emission tomography (PET); Algorithms; Animals; Diagnostic Techniques, Cardiovascular; Heart; Humans; Kinetics; Male; Normal Distribution; Positron-Emission Tomography; Rats; Rats, Inbred F344; Rubidium Radioisotopes; Signal Processing, Computer-Assisted; Time Factors;
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2012.2221463
Filename :
6323013
Link To Document :
بازگشت