Title :
Automated microfluidic sample stream position control for on-chip selective drug delivery
Author :
Moscelli, Nicola ; Ladisa, Nicola ; Vellekoop, Michael J.
Author_Institution :
Inst. of Sensors & Actuator Syst., Vienna Univ. of Technol., Vienna, Austria
Abstract :
In this paper we present a novel microfluidic system which is able to automatically control the position of a hydrodynamically focused non-coaxial sample stream within a microchannel for on-chip applications such as selective drug delivery. A colored sample stream is optically detected by a high definition camcorder mounted on a microscope (approximately 2 μm resolution). To determine sample stream position and width, the frames are grabbed and processed. To position the sample stream, volume driven syringe pumps are actuated via a PC implementing two different controllers, PI and Fuzzy. The microfluidic system has been identified by a non-linear ARX model. Closed-loop time domain experiments to accurately position a 25 μm wide sample stream within a 160 μm wide channel have been successfully carried out with both control systems.
Keywords :
PI control; drug delivery systems; fuzzy control; microfluidics; position control; video cameras; PI controller; automated microfluidic sample stream position control; closed loop time domain experiment; colored sample stream; high definition camcorder; noncoaxial sample stream; nonlinear ARX model; on-chip selective drug delivery; optical detection; volume driven syringe pump; Automatic control; Control systems; Drug delivery; Microchannel; Microfluidics; Nonlinear optics; Optical detectors; Optical pumping; Position control; System-on-a-chip; PI-GA; fuzzy; microfluidics; optical detection; sample stream position control;
Conference_Titel :
Computer Communication Control and Automation (3CA), 2010 International Symposium on
Conference_Location :
Tainan
Print_ISBN :
978-1-4244-5565-2
DOI :
10.1109/3CA.2010.5533770