Notice of RetractionThe effect of Sargassum fusiforme polysaccharides on the functioning of erythrocyte membrane of S180 mice by affecting Ca2+ channels

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

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To analyze the effect of Sargassum fusiforme polysaccharides (SFPS) on the functioning of erythrocyte membrane of S180 mice by affecting Ca²⁺ channels. A tumor mouse model was developed, and the mice were treated with high, medium, and low doses of SFPS. Changes in [Ca²⁺] in the erythrocytes in the tumor-bearing mice were measured using laser confocal scanning; changes in the content of sialic acid and the acitivities of ATPase were meausred using relevant test kits; changes in the level of erythrocyte membrane potential were analyzed using FCM; and changes in the complex mobility of erythrocytes were measured using HPCE. SFPS lowered the intracelluar [Ca²⁺] of erythrocytes in tumor-bearing mice, increased the content of sialic acid on surface of erythrocyte membrane, increased the acitivities of Na⁺,K⁺-ATPase and Ca²⁺, Mg²⁺-ATPase, and raised the level of erythrocyte membrane potential and the complex mobility of erythrocytes in elelctrophoresis. By affecting the Ca²⁺ channels, SFPS can increase the content of sialic acid on the surface of erythrocyte membrane. The sialic acid combines with Ca²⁺ to increase the activities of Na⁺,K⁺-ATPase and Ca²⁺, Mg²⁺-ATPase, resulting in a rise in the membrane potential of the erythrocytes and an increase in the complex mobility of the erythrocytes in electrophoresis, thus restoring many physiological and biochemical functions of the e- ythrocyte membrane. This may be one of the anti-tumor mechanisms of SFPS.