Measurement of kurtosis in renal apparent diffusion coefficient and the limitation of mono-exponential model for quantification

Conventional diffusion tensor imaging (DTI) measures water diffusion parameters base on a gaussian function. However, water movement in biological tissue is often non-gaussian and the non-gaussian behavior contain useful information related to tissue structure. This study is using the kidney of normal volunteers´ image to demonstrate the biexponential model. The kurtosis can denote the extent non-gaussianity of renal diffusion, so we use the many set of b-values to calculate the mean kurtosis image.