Analysis of T-wave amplitude adaptation to heart rate using RR-binning of long-term ECG recordings

The prognosis of patients with coronary artery disease at the early stage of the disease is a challenge of modern cardiology. There is an urgent need to risk stratify these patients. Holter technology is a cheap and cost effective tool to evaluate electrical abnormalities in the heart. We propose to investigate T-amplitude adaptation to heart rate (HR) using RR-binning. We used daytime recordings from healthy subjects and subjects with acute myocardial infarction (AMI) from the Telemetric and Holter ECG Warehouse. The AMI subjects were divided into two groups based on location of their infarction (group A: anterior or anterior lateral, group B: inferior or inferior lateral). Both AMI groups had acute and stable phase recordings. Population-based T-adaptation to HR was observed for healthy subjects (R² = 0.92) but was less pronounced for AMI subjects: Group A- R²_acute = 0.56 and R²_stable = 0.00, and Group B- R²_acute = 0.57 and R²_stable = 0.33.