Atrial fibrillation-based electrical remodeling in a computer model of the human atrium

Atrial fibrillation (AF) is a common pathology. AF modifies the electrophysiological properties of cells (remodeling) promoting the occurrence and maintenance of AF. Electrical remodeling includes changes in I_Ca,L, I_to, I_K1 and I_K,ACh.These effects were integrated in a human atrial computer model. Gap junction remodeling was considered in the conductivity of the monodomain equation calculating excitation. Specific features were calculated to determine the risk of AF initiation and perpetuation. ERP was reduced from 330ms to 103ms. CV was low ered from 755mm/s to 608mm/s. The WL reduction was even higher (from 249mm to 63mm) leading to a higher probability of occurrence and maintenance of AF. A maximum of 7 spirals waves were initiated leading to apeak in the power spectrum at 10.32Hz. The computer model underlines the relevance of remodeling in AF chronification. The results add to the knowledge of AF maintenance. Our model might prove to be a tool for the development of novel therapeutic strategies.