Sodium-calcium exchange tail current in atrial myocytes of the rabbit — An index of subsarcolemmal calcium concentrations?

Author

Earm, Yung E. ; Ho, Won Kyung ; So, Insuk ; Leem, Chae Hun

Author_Institution

Dept. of Physiol., Seoul Nat. Univ. Coll. of Med., Seoul, South Korea

Volume

1

fYear

1992

fDate

Oct. 29 1992-Nov. 1 1992

Firstpage

99

Lastpage

100

Abstract

In cardiac cells, sodium-calcium exchange is important in regulation of intracellular calcium concentration as a primary mechanism of calcium extrusion. In the present study, the effect of calcium buffers, EGTA, BAPTA and Indo-1 on the process that activates the inward Na-Ca exchange current was investigated by analyzing the voltage dependence and the time course of the tail currents, and the change of the inward tail current in hypoxic condition and in various cardiomyopathic conditions (adriamycin and hyperthyroidism). Whole cell patch clamp technique with intracellular perfusion was used in rabbit atrial myocytes.

Keywords

bioelectric potentials; biomembrane transport; calcium; cardiology; diseases; haemorheology; muscle; sodium; BAPTA; Ca; EGTA; Indo-1; Na; adriamycin; atrial myocytes; cardiac cells; cardiomyopathic conditions; exchange tail current; hyperthyroidism; intracellular perfusion; rabbit; subsarcolemmal calcium concentrations; voltage dependence; whole cell patch clamp technique;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE

Conference_Location

Paris

Print_ISBN

0-7803-0785-2

Electronic_ISBN

0-7803-0816-6

Type

conf

DOI

10.1109/IEMBS.1992.5760875

Filename

5760875