Closed loop polarimetric glucose sensing using the pockels effect

The development of a noninvasive glucose sensor is important for the regulation and control of diabetes. In this investigation, we present the results of a potential noninvasive optical polarimetric glucose sensor. The results were obtained using a single Pockels to modulate the signal and to close the loop in this system. A good linear relationship was seen between the output voltage of the sensor and the in vitro concentration of glucose for the hyperglycemic range (100-600 mg/dl). In addition, the calibration curves for this system showed excellent linearity with a correlation coefficient (R²) of 0.999 for a rotation range of -800 mdeg to 800 mdeg.