Title :
Determining the absorption coefficient of hemoglobin derivatives with integrated optic waveguide sensor
Author :
Kang, Shin-Won ; Sasaki, Keisuke ; Minamitani, Haruyuki
Author_Institution :
Dept..of Biomed. Eng., Keio Univ., Yokohama, Japan
fDate :
Oct. 29 1992-Nov. 1 1992
Abstract :
A simple method of determining the absorption coefficient of absorbing aqueous biochemicals is proposed as an application of the complex propagation constant of guided wave in a thin-film optical waveguide. It was designed to consecutively change the interaction length between the evanescent field and the sample, and evaluated by prism couplers. The response linearly depends on the interaction length and the total hemoglobin concentration(THb ) of hemoglobin derivatives. The determined absorption coefficients fairly well coincide with the values obtained by the conventional transmission measurement.
Keywords :
absorption coefficients; biochemistry; biosensors; chemical sensors; molecular biophysics; optical couplers; optical planar waveguides; optical prisms; optical sensors; proteins; absorbing aqueous biochemicals; absorption coefficient; evanescent field; hemoglobin concentration; hemoglobin derivatives; integrated optic waveguide sensor; prism couplers; thin-film optical waveguide; transmission measurement; Chemical lasers; Laser modes; Optical coupling; Optical sensors; Optical variables control; Optical waveguides; Sputtering;
Conference_Titel :
Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE
Conference_Location :
Paris
Print_ISBN :
0-7803-0785-2
Electronic_ISBN :
0-7803-0816-6
DOI :
10.1109/IEMBS.1992.5760911
