Title :
Steric effects at acyclic and bridgehead carbons attached to carbonyls
Author :
Kristol, David S. ; Fisher, Mark A. ; Yadav, Janardan ; Laxminarayan, Swamy ; Perlmutter, Howard
Author_Institution :
New Jersey Inst. of Technol., Newark, NJ, USA
fDate :
Oct. 29 1992-Nov. 1 1992
Abstract :
The rates of alkaline hydrolysis of seven acyclic and bridgehead esters of p-nitrophenyl carboxylic acids have been kinetically found to vary inversely with the size of the substituent R group. Computer assisted molecular modeling techniques were used to suggest a steric and electrostatic rationale for the effect of R group size upon the rate of hydrolysis.
Keywords :
chemical reactions; chemistry computing; organic compounds; R group size; acyclic carbons; acyclic esters; alkaline hydrolysis; bridgehead carbons; carbonyls; electrostatic rationale; molecular modeling techniques; p-nitrophenyl carboxylic acids; steric effects;
Conference_Titel :
Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE
Conference_Location :
Paris
Print_ISBN :
0-7803-0785-2
Electronic_ISBN :
0-7803-0816-6
DOI :
10.1109/IEMBS.1992.5760930
