Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers

Author

Douek, Philippe C. ; Correa, Rosaly ; Unger, Ellis F. ; Neville, Richard ; Banai, Shmuel ; Epstein, Stephen E. ; Leon, Martin B. ; Bonner, Robert F.

Author_Institution

Biomed. Eng. & Instrum. Program, Nat. Inst. of Health, Bethesda, MD, USA

Volume

1

fYear

1992

fDate

Oct. 29 1992-Nov. 1 1992

Firstpage

314

Lastpage

315

Abstract

Pulsed infrared localized thermal lesions heating to 30°C above SMC proliferation in Neointimal proliferation laser irradiation induced in arteries by transiently ambient and subsequent rabbits by 3-4 weeks. exhibited a clear dose dependence both as laser fluence was increased (R=0.83) and for a fixed surface irradiation as the depth of the nearest arterial media was decreased (R=0.95). Thermal injury to the arterial wall is shown to be potent stimulus for SMC proliferation, favoring reduction in energies used in laser or thermal angioplasty.

Keywords

biothermics; blood vessels; cellular effects of radiation; dosimetry; injuries; laser applications in medicine; muscle; radiation therapy; SMC proliferation; arterial wall; energy reduction; fixed surface irradiation; laser angioplasty; laser fluence; localized thermal lesion heating; neointimal proliferation laser irradiation; pulsed infrared laser; smooth muscle cell proliferation; thermal angioplasty; thermal injury; time 3 week to 4 week; Arteries; Ear; Heating; Lasers; Lesions; Surgery; Transient analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE

Conference_Location

Paris

Print_ISBN

0-7803-0785-2

Electronic_ISBN

0-7803-0816-6

Type

conf

DOI

10.1109/IEMBS.1992.5760981

Filename

5760981