Influence of Vecuronium Bromide on the ED50 for electrical ventricular defibrillation in the canine model

Paralytic agents are increasingly being used in animal studies of electrical ventricular defibrillation. Likewise, patients often have internal defibrillators implanted in conjunction with other heart surgery such as coronary artery bypass grafting (CABG). These patients usually will have been given a paralytic agent which is still present in the circulatory system. This study was undertaken to ascertain whether Vecuronium Bromide has an effect on the mean effective dose (ED50) for electrical defibrillation in a dog model. This study shows that in this model, Vecuronium Bromide does not effect the ED50 for EVD.