DocumentCode
545063
Title
A physiologic-based circuit model of the postsynaptic region at the neuromuscular junction
Author
Levine, Michael D. ; Eisenberg, Marvin F. ; Fare, Thomas L.
Author_Institution
Dept. of Electr. Eng./Comput. Sci., George Washington Univ., Washington, DC, USA
Volume
4
fYear
1992
fDate
Oct. 29 1992-Nov. 1 1992
Firstpage
1602
Lastpage
1603
Abstract
A metal-oxide-semiconductor field-effect transistor (MOSFET) is used as the circuit analog to simulate a group of excitatory transmitter-gated ion channels. This analog is incorporated into a circuit model of the postsynaptic membrane at the neuromuscular junction. Simulation of the model yields an output representing the overall membrane potential of the postsynaptic region. Simulation is performed for the normal and pathologic (myasthenia gravis) states.
Keywords
MOSFET circuits; biomedical electronics; biomembranes; neuromuscular stimulation; physiology; MOSFET; circuit analog; excitatory transmitter-gated ion channels; metal-oxide-semiconductor field-effect transistor; myasthenia gravis states; neuromuscular junction; physiologic-based circuit model; postsynaptic membrane potential; Extracellular;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1992 14th Annual International Conference of the IEEE
Conference_Location
Paris
Print_ISBN
0-7803-0785-2
Type
conf
DOI
10.1109/IEMBS.1992.5761944
Filename
5761944
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