DocumentCode
549638
Title
Design of Robust Metabolic Pathways
Author
Umeton, Renato ; Stracquadanio, Giovanni ; Sorathiya, Anilkumar ; Papini, Alessio ; Liò, Pietro ; Nicosia, Giuseppe
Author_Institution
Dept. of Biol. Eng., MIT, Cambridge, MA, USA
fYear
2011
fDate
5-9 June 2011
Firstpage
747
Lastpage
752
Abstract
In this paper we investigate plant photosynthesis and microbial fuel cells. We report the following: 1) we introduce and validate a novel multi-objective optimization algorithm, PMO2; 2) in photosynthesis we increase the yield of 135%, while in Geobacter sulfurreducens we determine the tradeoff for growth versus redox properties; 3) finally, we discuss Pareto-Front as an estimator of robust metabolic pathways.
Keywords
biochemistry; biotechnology; botany; chemical reactions; fuel cells; optimisation; photosynthesis; Geobacter sulfurreducens; PMO2; Pareto-front; microbial fuel cells; multiobjective optimization algorithm; plant photosynthesis; redox properties; robust metabolic pathways; Algorithm design and analysis; Carbon; Nitrogen; Optimization; Proteins; Robustness; Carbon metabolism; Geobacter sulfurreducens; Metabolic engineering; Multi-objective Optimization; Mutational Robustness;
fLanguage
English
Publisher
ieee
Conference_Titel
Design Automation Conference (DAC), 2011 48th ACM/EDAC/IEEE
Conference_Location
New York, NY
ISSN
0738-100x
Print_ISBN
978-1-4503-0636-2
Type
conf
Filename
5981995
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