Title :
A 256 channel magnetoresistive biosensor microarray for quantitative proteomics
Author :
Hall, Drew A. ; Gaster, Richard S. ; Osterfeld, Sebastian J. ; Makinwa, Kofi ; Wang, Shan X. ; Murmann, Boris
Author_Institution :
Stanford Univ., Stanford, CA, USA
Abstract :
This work presents a high sensitivity biosensing platform for quantitative proteomics. Biomolecules labeled with magnetic nanoparticle (MNP) tags are quantitatively sensed by a high density array of 256 giant magnetoresistive spin-valve (GMR SV) sensors connected to a 0.18 μm CMOS sensor interface featuring 16 ΣΔ modulators with 84 dB dynamic range. The performance of the system is demonstrated through detection of a spiked tumor biomarker, epithelial cell adhesion molecule (EpCAM), at concentrations below 10 picomolar (pM).
Keywords :
adhesion; biomechanics; biosensors; cellular biophysics; lab-on-a-chip; magnetic particles; magnetic sensors; nanobiotechnology; nanoparticles; proteomics; spin valves; tumours; 256 channel magnetoresistive biosensor microarray; CMOS sensor; epithelial cell adhesion molecule; giant magnetoresistive spin-valve sensor; magnetic nanoparticle labeled biomolecules; magnetic nanoparticle tags; quantitative proteomics; size 0.18 mum; spiked tumor biomarker; Biosensors; Capacitors; Magnetic sensors; Modulation; Sensor arrays;
Conference_Titel :
VLSI Circuits (VLSIC), 2011 Symposium on
Conference_Location :
Honolulu, HI
Print_ISBN :
978-1-61284-175-5
