DocumentCode
549832
Title
Magnetic relaxation detector for microbead labels in biomedical assays
Author
Liu, Paul ; Skucha, Karl ; Duan, Yida ; Megens, Mischa ; Kim, Jungkyu ; Izyumin, Igor ; Gambini, Simone ; Boser, Bernhard
Author_Institution
EECS Dept, UC Berkeley, Berkeley, CA, USA
fYear
2011
fDate
15-17 June 2011
Firstpage
176
Lastpage
177
Abstract
A Hall-effect biosensor based on magnetic label detection is implemented in 0.18 μm CMOS. No external magnet, reference sensor or calibration is required. The sensor offset is suppressed to sub-μV by a mixed-signal feedback loop and correlated double sampling (CDS). Flicker noise and thermal noise are rejected by CDS and averaging. A single 4.5 μm bead is detected in 16 ms with a probability of error <;0.1%.
Keywords
CMOS integrated circuits; Hall effect devices; biomedical equipment; biomedical measurement; biosensors; magnetic relaxation; magnetic sensors; CDS; CMOS; Hall effect biosensor; biomedical assays; correlated double sampling; flicker noise rejection; magnetic label detection; magnetic relaxation detector; microbead labels; mixed signal feedback loop; thermal noise rejection; Arrays; CMOS integrated circuits; Magnetic domains; Magnetometers; Noise; Temperature measurement; Thermal noise;
fLanguage
English
Publisher
ieee
Conference_Titel
VLSI Circuits (VLSIC), 2011 Symposium on
Conference_Location
Honolulu, HI
ISSN
2158-5601
Print_ISBN
978-1-61284-175-5
Type
conf
Filename
5986094
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