Title :
Magnetic relaxation detector for microbead labels in biomedical assays
Author :
Liu, Paul ; Skucha, Karl ; Duan, Yida ; Megens, Mischa ; Kim, Jungkyu ; Izyumin, Igor ; Gambini, Simone ; Boser, Bernhard
Author_Institution :
EECS Dept, UC Berkeley, Berkeley, CA, USA
Abstract :
A Hall-effect biosensor based on magnetic label detection is implemented in 0.18 μm CMOS. No external magnet, reference sensor or calibration is required. The sensor offset is suppressed to sub-μV by a mixed-signal feedback loop and correlated double sampling (CDS). Flicker noise and thermal noise are rejected by CDS and averaging. A single 4.5 μm bead is detected in 16 ms with a probability of error <;0.1%.
Keywords :
CMOS integrated circuits; Hall effect devices; biomedical equipment; biomedical measurement; biosensors; magnetic relaxation; magnetic sensors; CDS; CMOS; Hall effect biosensor; biomedical assays; correlated double sampling; flicker noise rejection; magnetic label detection; magnetic relaxation detector; microbead labels; mixed signal feedback loop; thermal noise rejection; Arrays; CMOS integrated circuits; Magnetic domains; Magnetometers; Noise; Temperature measurement; Thermal noise;
Conference_Titel :
VLSI Circuits (VLSIC), 2011 Symposium on
Conference_Location :
Honolulu, HI
Print_ISBN :
978-1-61284-175-5
