Piezo-powered Micro-dissection system with ultrasonic vibration

In biomedical areas, Micro-dissection technology plays an important role for Cancer Genomics, through which pure population of targeted cells can be procured from tissue sections for subsequent analysis. In this paper, a novel Piezo-powered Micro-dissection system using ultrasonic vibration was developed. First, the Piezo-powered Micro-dissection principle and system construction will be introduced briefly. Then the key component of the system, piezo-powered micro-dissection tool, is proposed in detail. The micro-dissection tool could vibrate with the frequency scope from 0.5k to40K and the amplitude scope from 0 to 2μm. Finally, a variety of experiments about bio-micro-dissection on liver tissue slice were carried out, and the experiments show the feasibility of the micro-dissection method with ultrasonic vibration. The new micro-dissection method can be adopted in the bio-micro-manipulation field and it can also significantly promote the development of Biomedical Engineering.