Nonlinear optical imaging with a scanning fiber-optic endomicroscope

Author

Murari, Kartikeya ; Zhang, Yuying ; Xi, Jiefeng ; Chen, Yongping ; Kakkad, Samata ; Bhujwalla, Zaver ; Glunde, Kristine ; Ming-Jun Li ; Li, Xingde

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA

fYear

2011

fDate

4-8 July 2011

Firstpage

446

Lastpage

447

Abstract

We present recent updates on our work on developing a fully integrated, miniaturized fiber-optic scanning endomicroscope for performing nonlinear optical imaging including two-photon fluorescence and second harmonic generation. We describe our design approaches for significantly improving signal collection efficiency and resolution. Preliminary tissue imaging results will be presented to demonstrate the potential of the nonlinear endomicroscopy technology for diagnostics and image-based guidance.

Keywords

biological tissues; biomedical optical imaging; fluorescence; image resolution; integrated optics; medical image processing; optical fibres; optical harmonic generation; optical microscopy; two-photon processes; image-based guidance; miniaturized fiber-optic scanning endomicroscope; nonlinear endomicroscopy technology; nonlinear optical imaging; second harmonic generation; signal collection efficiency; signal resolution; tissue imaging; two-photon fluorescence; Band pass filters; Couplings; Optical fiber filters; Optical fibers; Optical imaging; Stimulated emission;

fLanguage

English

Publisher

ieee

Conference_Titel

Opto-Electronics and Communications Conference (OECC), 2011 16th

Conference_Location

Kaohsiung

Print_ISBN

978-1-61284-288-2

Electronic_ISBN

978-986-02-8974-9

Type

conf

Filename

6015206