Title :
Nonlinear optical imaging with a scanning fiber-optic endomicroscope
Author :
Murari, Kartikeya ; Zhang, Yuying ; Xi, Jiefeng ; Chen, Yongping ; Kakkad, Samata ; Bhujwalla, Zaver ; Glunde, Kristine ; Ming-Jun Li ; Li, Xingde
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
We present recent updates on our work on developing a fully integrated, miniaturized fiber-optic scanning endomicroscope for performing nonlinear optical imaging including two-photon fluorescence and second harmonic generation. We describe our design approaches for significantly improving signal collection efficiency and resolution. Preliminary tissue imaging results will be presented to demonstrate the potential of the nonlinear endomicroscopy technology for diagnostics and image-based guidance.
Keywords :
biological tissues; biomedical optical imaging; fluorescence; image resolution; integrated optics; medical image processing; optical fibres; optical harmonic generation; optical microscopy; two-photon processes; image-based guidance; miniaturized fiber-optic scanning endomicroscope; nonlinear endomicroscopy technology; nonlinear optical imaging; second harmonic generation; signal collection efficiency; signal resolution; tissue imaging; two-photon fluorescence; Band pass filters; Couplings; Optical fiber filters; Optical fibers; Optical imaging; Stimulated emission;
Conference_Titel :
Opto-Electronics and Communications Conference (OECC), 2011 16th
Conference_Location :
Kaohsiung
Print_ISBN :
978-1-61284-288-2
Electronic_ISBN :
978-986-02-8974-9
