Quantitative Mapping of Pharmaceutical Cocrystals Within Cellulose by Terahertz Spectroscopy

Author

Kim, J.-Y. ; Boenawan, Resza ; Ueno, Yukiko ; Ajito, K.

Author_Institution

NTT Microsyst. Integration Labs., NTT Corp., Atsugi, Japan

Volume

32

Issue

20

fYear

2014

fDate

Oct.15, 15 2014

Firstpage

3768

Lastpage

3773

Abstract

Terahertz (THz) spectroscopy is a powerful tool for identifying inter-molecular hydrogen bonds in pharmaceutical materials. Here, we present quantitative chemical imaging of multicomponent pellets composed of pharmaceutical cocrystals and cellulose by THz spectroscopy. The stabilized THz time-domain spectroscope with laser beam monitoring and feedback supports accurate absorption spectra measurement. The linearity of THz absorptions of cocrystals and cellulose against the concentration are experimentally verified. In addition, the concentrations of the materials inside pellets are quantitatively extracted and mapped from the THz spectroscopic image by linear regression using reference THz spectra obtained for cocrystals and diluents.

Keywords

laser feedback; measurement by laser beam; regression analysis; terahertz wave imaging; terahertz wave spectra; cellulose; diluents; intermolecular hydrogen bonds; laser beam feedback; laser beam monitoring; linear regression; multicomponent pellets; pharmaceutical cocrystal mapping; quantitative chemical imaging; terahertz absorption spectra measurement; terahertz time-domain spectroscopic image; Absorption; Imaging; Materials; Measurement by laser beam; Pharmaceuticals; Spectroscopy; Weight measurement; Cellulose; chemical imaging; optoelectronics; quantitative chemical analysis; terahertz; time-domain spectroscopy;

fLanguage

English

Journal_Title

Lightwave Technology, Journal of

Publisher

ieee

ISSN

0733-8724

Type

jour

DOI

10.1109/JLT.2014.2314139

Filename

6780596