Effect of hesperidin extraction on the bone marrow polychromatophilic erythroblast micronucleus of exercise fatigue

To study the effect of hesperidin extracted from the peel of Gannan kumquat on the bone marrow polychromatophilic erythroblast micronucleus of exercise fatigue. Methods: Hesperidin was extracted from the peel of kumquat by ultrasound and ethanol precipitation and was detected qualitatively by the high performance liquid chromatogramphy. Effect of hesperidin on the micronuclear rate of polychromatophilic erythroblasts of rat marrow was used by the micronucleus test. Results: The rats of exercise fatigue had some phenomena, such as depilation, tired appearance, low appetite, degressive locomotory capacity and slow-moving growth of body weight. Exercise fatigue caused the rats to increase the micronuclear rate of marrow polychromatophilic erythroblasts (P <; 0.001). Hesperidin decreased the micronuclear rate of marrow polychromatophilic erythroblasts (P <; 0.05-0.001). Conclusion: Hesperidin had inhibited the exercise fatigue through inhibiting the production of micronuclear rate of marrow polychromatophilic erythroblasts.