• DocumentCode
    557559
  • Title

    The integration analysis of multiple species phosphorylation sites

  • Author

    Liu, Ying

  • Author_Institution
    Found. Dept., ZheJiang TongJi Vocational Coll. of Sci. & Technol., Hangzhou, China
  • Volume
    3
  • fYear
    2011
  • fDate
    15-17 Oct. 2011
  • Firstpage
    1609
  • Lastpage
    1613
  • Abstract
    Protein phosphorylation plays a key role in sucrose-mediated transcriptional regulation of a phloem-specific proton-sucrose symporter. We evaluate the conservation of phosphorylation sites and its surrounding amino acids stretch through statistic analysis in this paper. Ten eukaryotic model species protein sequences were downloaded and the sequences which have ortholog were reserved for the anaysis. To compare the conservation of phosphorylation sites and its flanking sequences, we create two indexes named conservation score (C-score) and conservation Z-score (CZ-score) to evaluate the conservation of phosphorylation sites and its flanking sequences. The result shows that phosphorylated sites may be much better conserved than the unphosphorylated sites. The flanking sequences of phosphorylation site don´t reflect the same trend.
  • Keywords
    integration; molecular biophysics; proteins; statistical analysis; amino acids; conservation Z-score; conservation score; eukaryotic model species protein sequences; flanking sequences; integration analysis; multiple species phosphorylation sites; phloem-specific proton-sucrose symporter; protein phosphorylation; statistic analysis; sucrose-mediated transcriptional regulation; Bioinformatics; Databases; Humans; Marine animals; Mice; Proteins; Proteomics; comservation; flanking sequences; phosphorylation sites;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on
  • Conference_Location
    Shanghai
  • Print_ISBN
    978-1-4244-9351-7
  • Type

    conf

  • DOI
    10.1109/BMEI.2011.6098613
  • Filename
    6098613