Study of simulation technology for myocardial ion channels on pharmacological effects

Computational models of the mammalian ventricular myocyte have become important tools for understanding the biophysical basis of the ventricular action potential (AP), for relating changes in gene/protein expression and effects of gene mutations to alterations of AP and calcium transient morphology, and for investigating mechanisms of arrhythmia. We established the computational model of heart failure and simulated the electrophysiological effects on the action potential of the main myocardial ion channels according to the action of class III antiarrhythmic drugs. This work could be used to study the pharmacological effects of heart disease drugs on transmural propagation and to develop a simulation tool for developing the new drugs for heart diseases.