Title :
Genome-wide methylation analysis using multiple tumor tissues
Author :
Inaoka, Hidenori ; Fukuoka, Yutaka
Author_Institution :
Allied Health Sci., Kitasato Univ., Kanagawa, Japan
Abstract :
DNA methylation plays an essential role in the regulation of gene transcription. Recent findings suggest that aberrant DNA methylation is closely related to carcinogenesis and cancer progression. Using publicly available data, genome-wide DNA methylation analysis of tumor and corresponding normal tissues was performed in multiple cancers. 114 varied-in-tumor CpG sites were commonly found in all the three cancers. The genes located near or in these common CpG sites were functionally clustered. Nearly half of the genes were closely related to zinc finger proteins.
Keywords :
DNA; biochemistry; bioinformatics; cancer; genetics; genomics; molecular biophysics; proteins; tumours; CpG sites; cancer progression; carcinogenesis; gene transcription regulation; genome-wide DNA methylation analysis; multiple tumor tissues; normal tissues; zinc finger proteins; Bioinformatics; Cancer; DNA; Fingers; Genomics; Tumors; Zinc; DNA methylation; gene transcription; zinc finger protein;
Conference_Titel :
SICE Annual Conference (SICE), 2012 Proceedings of
Conference_Location :
Akita
Print_ISBN :
978-1-4673-2259-1