Title :
The topological features of nonessential-nonhub proteins in the protein-protein interaction network
Author :
Yun-yuan, Dong ; Jun, Yang ; Qi-jun, Liu ; Zheng-hua, Wang
Author_Institution :
Coll. of Comput., Nat. Univ. of Defense Technol., Changsha, China
Abstract :
One of the important problems in system biology is to discover the relationship between topological properties and functional features of proteins in protein-protein interaction (PPI) networks. There are many essential-nonhub proteins and lots of nonessential-nonhub proteins in the PPI network. Both essential-nonhub proteins and nonessential-nonhub proteins are low-connectivity proteins, but they have different lethality. In order to explain why nonessential-nonhub proteins are not essential, we compare them with essential-nonhub proteins from topological view. The comparison results show that there are statistical differences between nonessential-nonhub proteins and essential-nonhub proteins in centrality measures and clustering coefficient.
Keywords :
molecular biophysics; proteins; statistical analysis; centrality measurement; clustering coefficient; essential-nonhub proteins; low-connectivity proteins; nonessential-nonhub proteins; protein-protein interaction network; statistical difference; system biology; topological features; topological properties; Bioinformatics; Educational institutions; Genomics; Integrated circuits; Nickel; Organisms; Proteins; centrality measure; clustering coefficient; essential-nonhub protein; nonessential-nonhub protein; protein-protein interaction network;
Conference_Titel :
System Science, Engineering Design and Manufacturing Informatization (ICSEM), 2012 3rd International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4673-0914-1
DOI :
10.1109/ICSSEM.2012.6340764
