Comprehensive human membrane protein database

Membrane proteins are an important protein group involved in cell signaling, molecule transport, and cell-cell communication and regarded as very important pharmaceutical targets. However, most membrane protein resources are built for specific function groups and it is hard to find comprehensive information about membrane proteins. This circumstance hampers the search for both the general and specific characteristics of membrane proteins, which characteristics may provide critical information for the investigation of novel functions or drug targets. We collected 28,701 human membrane proteins from various sources and suggest 9,616 novel candidates using the information in collected proteins and orthologs from 51 other species. We also annotated various characteristics of membrane proteins including their conserved motifs and domains, functions, related cellular processes, and associated diseases. This database is freely available at http://fcode.kaist.ac.kr/chmpd.