Title :
Comprehensive human membrane protein database
Author :
Kim, Min-sung ; Yi, Gwan-Su
Author_Institution :
Dept. of Inf. & Commun. Eng, KAIST, Daejeon, South Korea
Abstract :
Membrane proteins are an important protein group involved in cell signaling, molecule transport, and cell-cell communication and regarded as very important pharmaceutical targets. However, most membrane protein resources are built for specific function groups and it is hard to find comprehensive information about membrane proteins. This circumstance hampers the search for both the general and specific characteristics of membrane proteins, which characteristics may provide critical information for the investigation of novel functions or drug targets. We collected 28,701 human membrane proteins from various sources and suggest 9,616 novel candidates using the information in collected proteins and orthologs from 51 other species. We also annotated various characteristics of membrane proteins including their conserved motifs and domains, functions, related cellular processes, and associated diseases. This database is freely available at http://fcode.kaist.ac.kr/chmpd.
Keywords :
Internet; bioinformatics; biomembranes; diseases; information services; molecular biophysics; pharmaceuticals; proteins; cell signaling; cell-cell communication; diseases; drug targets; human membrane protein database; membrane protein characteristics; membrane proteins; molecule transport; pharmaceutical targets; protein cellular processes; protein domains; protein functions; protein group; protein motifs; Biomembranes; Databases; Humans; Pharmaceuticals; Protein engineering; Proteins; Topology; Human Membrane Protein; Interaction Type with Membrane; Novel Membrane Protein Prediction; Pharamacetucial Research;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2012 IEEE International Conference on
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-2559-2
Electronic_ISBN :
978-1-4673-2558-5
DOI :
10.1109/BIBM.2012.6392683
