Title :
Nano carriers based targeted drug delivery path planning using hybrid particle swarm optimizer and artificial magnetic fields
Author :
Hassan, Syed ; Yoon, Juagwon
Author_Institution :
Sch. of Mech. & Aerosp. Eng., Gyeongsang Nat. Univ., Jinju, South Korea
Abstract :
When performing drug delivery for a certain disease, the effectiveness of a drug primarily depends on the affected cell, targeted doze and drug release time. In this paper, a novel optimum or near optimum real time targeted drug delivery system is proposed. Targeted path planning algorithm for nano particles based on particle swarm optimization approach and artificial potential field concepts used as virtual MRI (magnetic resonance Imaging) is proposed to solve the obstacle free targeted drug delivery process in a 3d virtual environment. At first stage 3d path planning scheme based on attractive and repulsive artificial potential field for obstacle free path in certain blood vessels is used. Later, an optimization process for all the discovered trajectories by combining particle swarm optimization algorithm is performed to generate an optimal path. Simulation results showed that proposed algorithm has higher success rate in targeting the drugs with a faster convergence rate towards the optimal solution by consuming less computation time (near optimal).
Keywords :
biomedical MRI; drug delivery systems; particle swarm optimisation; path planning; virtual reality; 3d path planning scheme; affected cell; artificial magnetic fields; artificial potential field concepts; drug release time; hybrid particle swarm optimizer; magnetic resonance imaging; nano carriers based targeted drug delivery path planning; obstacle free path; obstacle free targeted drug delivery process; targeted doze; virtual MRI; Drugs; Force; Magnetic resonance imaging; Optimization; Particle swarm optimization; Path planning; Targeted drug delivery; Nano particles; PSO; Targeted drug delivery; Virtual Reality;
Conference_Titel :
Control, Automation and Systems (ICCAS), 2012 12th International Conference on
Conference_Location :
JeJu Island
Print_ISBN :
978-1-4673-2247-8