Title :
A Linear Approach to Multi-Panel Sensing in Personalized Therapy for Cancer Treatment
Author :
Baj-Rossi, Camilla ; De Micheli, G. ; Carrara, Sandro
Author_Institution :
Swiss Fed. Inst. of Technol., EPFL, Lausanne, Switzerland
Abstract :
In this paper, a new approach for evaluating the performance of a multi-panel biosensor using linear algebra is presented. With a system-level mathematical analysis based on graphs and linear algebra, we formulate a new approach for contributions decoupling in a multi-panel biochip for simultaneous detection of anti-cancer drugs, avoiding redundancy and interaction between enzymes. Experimental results have been used to validate the model.
Keywords :
biosensors; cancer; drugs; enzymes; graphs; lab-on-a-chip; linear algebra; patient treatment; anti-cancer drugs; cancer treatment; enzymes; graphs; linear algebra; multipanel biochip; multipanel biosensor; multipanel sensing; personalized therapy; system-level mathematical analysis; Biochemistry; Biosensors; Drugs; Electrodes; Sensor arrays; Cytochrome P450 biosensor; condition number; limit of detection; linear system; multiplexed drugs detection; personalized therapy;
Journal_Title :
Sensors Journal, IEEE
DOI :
10.1109/JSEN.2013.2274873
