Title :
Feasibility of non-invasive determination of the stability of propagation reserve in patients
Author :
Idriss, S.F. ; Krassowska Neu, W. ; Varadarajan, V. ; Antonijevic, Todor ; Gilani, Syed Shiraz ; Starobin, Joseph M.
Author_Institution :
Duke Univ., Durham, NC, USA
Abstract :
This study investigates the feasibility of using surface ECG recordings to assess stability of cardiac propagation. Our novel method customizes a reaction-diffusion model of cardiac excitation using measurements of patient´s repolarization dynamics. The customized model determines the stability-of-propagation reserve (SoPR) that measures the proximity of the patient´s minimum level of refractoriness to the critical level associated with conduction instability. Using measurements from 15 patients, we compared SoPRs determined from the unipolar intracardiac electrograms and from the surface ECG leads. SoPRs computed from intracardiac and surface measurements correlated, and a formula was developed that estimated the intracardiac SoPR from surface measurements with 5% accuracy. Thus, this study may lead to new noninvasive tests for the risk of sudden cardiac death.
Keywords :
biodiffusion; electrical conductivity; electrocardiography; medical signal processing; reaction-diffusion systems; cardiac excitation; cardiac propagation; conduction instability; customized model; intracardiac SoPR; intracardiac measurements; noninvasive determination; noninvasive tests; patient repolarization dynamics; reaction-diffusion model; stability-of-propagation reserve; sudden cardiac death; surface ECG leads; surface ECG recordings; surface measurements; unipolar intracardiac electrograms; Approximation methods; Computational modeling; Electrocardiography; Fitting; Heart; Mathematical model; Stability analysis;
Conference_Titel :
Computing in Cardiology (CinC), 2012
Conference_Location :
Krakow
Print_ISBN :
978-1-4673-2076-4