Title :
Molecular phenotypic portraits - Exploring the ‘OMES’ with individual resolution
Author :
Binder, H. ; Hopp, L. ; Cakir, V. ; Fasold, M. ; von Bergen, M. ; Wirth, H.
Author_Institution :
Interdiscipl. Centre for Bioinf., Univ. Leipzig, Leipzig, Germany
Abstract :
Self organizing maps (SOMs) portrait molecular phenotypes with individual resolution. We demonstrate the potency of the method in selected applications characterizing the diversity of gene expression in different tissues and cancer subtypes, mRNA and miRNA fingerprints of stem cells, the proteome landscape of algae and genomic relations between humans from different populations. It is further shown that SOM portraiting provides a comprehensive frame to describe development, differentiation and diversity in space and/or time.
Keywords :
DNA; RNA; biological tissues; cancer; cellular biophysics; genetics; genomics; medical computing; microorganisms; proteins; proteomics; self-organising feature maps; algae; cancer subtypes; gene expression; genomic relations; mRNA fingerprints; miRNA fingerprints; molecular phenotypic portraits; portrait molecular phenotypes; proteome landscape; self-organizing maps; stem cells; tissue subtypes; Bioinformatics; Gene expression; Immune system; Prostate cancer; Stem cells; Tiles;
Conference_Titel :
Health Informatics and Bioinformatics (HIBIT), 2011 6th International Symposium on
Conference_Location :
Izmir
Print_ISBN :
978-2-4673-4394-4
DOI :
10.1109/HIBIT.2011.6450817
