CMOS-based implantable glucose monitoring device with improved performance and reduced invasiveness

Author

Kawamura, T. ; Masuda, K. ; Hirai, T. ; Ohta, Y. ; Motoyama, M. ; Takehara, H. ; Noda, T. ; Sasagawa, K. ; Tokuda, T. ; Okitsu, T. ; Takeuchi, S. ; Ohta, J.

Author_Institution

Grad. Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Nara, Japan

Volume

51

Issue

10

fYear

2015

fDate

5 14 2015

Firstpage

738

Lastpage

740

Abstract

An implantable glucose monitoring device based on a CMOS line sensor combined with a glucose-responsive fluorescent hydrogel is developed. An implantable glucose monitoring device with sufficient sensitivity and response time is realised, which is an improvement over the authors´ previous proof-of-concept device. A reduction of the sensor size made the device diameter injectable with a commercially available 16-gauge syringe needle. The sensor´s performance was confirmed through both in vitro and in vivo experiments.

Keywords

CMOS image sensors; CMOS integrated circuits; biomedical equipment; blood; diseases; fluorescence; hydrogels; needles; patient monitoring; sugar; CMOS line sensor; CMOS-based implantable glucose monitoring device; commercially available 16-gauge syringe needle; glucose-responsive fluorescent hydrogel; implantable glucose monitoring device; injectable device diameter; proof-of-concept device; sensor performance;

fLanguage

English

Journal_Title

Electronics Letters

Publisher

iet

ISSN

0013-5194

Type

jour

DOI

10.1049/el.2015.0612

Filename

7105440