DocumentCode :
59426
Title :
Author :
Murad, W. ; Singh, Rajdeep
Author_Institution :
Dept. of Comput. Sci., San Francisco State Univ., San Francisco, CA, USA
Volume :
12
Issue :
2
fYear :
2013
fDate :
Jun-13
Firstpage :
69
Lastpage :
71
Abstract :
MS2DB+ is an open-source platform-independent web application for determining, in polynomial time, the disulfide linkages in proteins using tandem mass spectrometry (MS/MS) data. It utilizes an efficient approximation algorithm which allows the consideration of multiple ion-types ( a, ao, a*, b, bo, b*, c, x, y, yo, y*, and z ) in the analysis. Once putative disulfide bonds are identified, a graph optimization approach is used to obtain the most likely global disulfide connectivity pattern. Availability-http://haddock2.sfsu.edu/~ms2db/disulfidebond/.
Keywords :
Internet; approximation theory; bonds (chemical); computational complexity; graph theory; mass spectroscopy; materials science computing; optimisation; proteins; public domain software; sulphur; MS/MS data; MS2DB+; S2; approximation algorithm; disulfide bond determination software; disulfide linkages; global disulfide connectivity pattern; graph optimization approach; multiion analysis; open-source platform-independent Web application; polynomial time; proteins; putative disulfide bonds; tandem mass spectrometry; Algorithm design and analysis; Approximation algorithms; Approximation methods; Ions; Optimization; Peptides; Proteins; Bioinformatics; disulfide bond; mass spectrometry; peptides; proteomics; Algorithms; Disulfides; Ions; Proteins; Software; Tandem Mass Spectrometry;
fLanguage :
English
Journal_Title :
NanoBioscience, IEEE Transactions on
Publisher :
ieee
ISSN :
1536-1241
Type :
jour
DOI :
10.1109/TNB.2012.2212029
Filename :
6335483
Link To Document :
