DocumentCode :
59545
Title :
A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic CMOS SoC for Real-Time Epileptic Seizure Control
Author :
Wei-Ming Chen ; Herming Chiueh ; Tsan-Jieh Chen ; Chia-Lun Ho ; Chi Jeng ; Ming-Dou Ker ; Chun-Yu Lin ; Ya-Chun Huang ; Chia-Wei Chou ; Tsun-Yuan Fan ; Ming-Seng Cheng ; Yue-Loong Hsin ; Sheng-Fu Liang ; Yu-Lin Wang ; Fu-Zen Shaw ; Yu-Hsing Huang ; Chia-H
Author_Institution :
Dept. of Electron. Eng., Nat. Chiao Tung Univ., Hsinchu, Taiwan
Volume :
49
Issue :
1
fYear :
2014
fDate :
Jan. 2014
Firstpage :
232
Lastpage :
247
Abstract :
An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC is composed of eight energy-efficient analog front-end amplifiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wireless power-and-data transmission system is also embedded. By leveraging T-connected pseudo-resistors, the high-pass (low-pass) cutoff frequency of the AFEAs can be adjusted from 0.1 to 10 Hz (0.8 to 7 kHz). The noise-efficiency factor (NEF) of the AFEA is 1.77, and the DMSAR ADC achieves an ENOB of 9.57 bits. The BSP extracts the epileptic features from time-domain entropy and frequency spectrum for seizure detection. A constant 30- μA stimulus current is delivered by closed-loop control. The acquired signals are transmitted with on-off keying (OOK) modulation at 4 Mbps over the MedRadio band for monitoring. A multi-LDO topology is adopted to mitigate the interferences across different power domains. The proposed SoC is fabricated in 0.18- μm CMOS and occupies 13.47 mm2. Verified on Long Evans rats, the proposed SoC dissipates 2.8 mW and achieves high detection accuracy (> 92%) within 0.8 s.
Keywords :
CMOS analogue integrated circuits; adaptive signal detection; amplifiers; amplitude shift keying; analogue-digital conversion; bioelectric phenomena; closed loop systems; delta modulation; electroencephalography; entropy; feature extraction; medical disorders; medical signal detection; medical signal processing; neurophysiology; prosthetic power supplies; resistors; system-on-chip; 10-b delta-modulated SAR ADC; AFEA; DMSAR ADC; ENOB; MedRadio band; OOK; T-connected pseudoresistors; adaptive high-voltage-tolerant stimulator; bit rate 4 Mbit/s; closed-loop control; configurable biosignal processor; current 30 muA; electrical stimulation; energy-efficient analog front-end amplifiers; epileptic feature extraction; frequency spectrum; high-pass cutoff frequency; iEEG; integrated 8-channel closed-loop neural-prosthetic CMOS SoC; long evans rats; low-pass cutoff frequency; multiLDO topology; noise-efficiency factor; on-off keying modulation; power domains; real-time epileptic seizure control; real-time intracranial EEG acquisition; seizure detection; signal acquisition; size 0.18 mum; stimulus current; system-on-Chip; time-domain entropy; wireless power-and-data transmission system; Accuracy; Biomedical electronics; Educational institutions; Feature extraction; Logic gates; Real-time systems; System-on-chip; Closed-loop control; epilepsy; neural prosthesis; neuron modulation; system-on-Chip (SoC); wireless power transmission;
fLanguage :
English
Journal_Title :
Solid-State Circuits, IEEE Journal of
Publisher :
ieee
ISSN :
0018-9200
Type :
jour
DOI :
10.1109/JSSC.2013.2284346
Filename :
6637111
Link To Document :
بازگشت