DocumentCode :
598236
Title :
Quantitative assessment of Diabetic Macular Edema using fluorescein leakage maps
Author :
Magdy, E. ; Agbedia, O.O. ; Ibrahim, Mohammad ; Nguyen, Q.D. ; Fahmy, Ahmed S.
Author_Institution :
Center for Inf. Sci., Nile Univ., Cairo, Egypt
fYear :
2012
fDate :
Sept. 30 2012-Oct. 3 2012
Firstpage :
2833
Lastpage :
2836
Abstract :
Diagnosis of Diabetic Macular Edema (DME) from Fundus Fluorescein Angiography (FFA) image sequences is a standard clinical practice. Nevertheless, current methods depend on subjective evaluation of the amount of fluorescein leakage in the images which lack reproducibility and require well-trained grader. In this work, we present a method for processing FFA images to generate a fluorescein leakage map that can be used for quantitative evaluation of DME. An essential step in the proposed method is to model the spatial distribution of the image intensity within the macula. This model, which represents the non-leaking structures, is then subtracted from the late timeframe image to enhance the areas of fluorescein leakage. The resulting difference image is then mapped with empirical linear transformation to produce a color Fluorescein Leakage Map (FLM) that can be used for quantitative assessment and detection of DME. The method was applied to 13 image sequences for 13 different patients. The resulting FLM maps were found to be correlated with the thickness maps produced by Optical Coherence Tomography (OCT). The relatively high correlation between the FLM and OCT maps show the potential and of using the developed method for quantitatively assess the DME in FFA image sequences.
Keywords :
diseases; image sequences; medical image processing; optical tomography; FFA image sequence; Optical Coherence Tomography; color Fluorescein Leakage Map; diabetic macular edema; fluorescein leakage maps; fundus fluorescein angiography; image intensity spatial distribution; late timeframe image; reproducibility; Angiography; Correlation; Diabetes; Image color analysis; Image sequences; Optical imaging; Retina; Diabetic Macular Edema; Digital Subtraction; Fluorescein Angiography; Optical Coherence Tomography;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Image Processing (ICIP), 2012 19th IEEE International Conference on
Conference_Location :
Orlando, FL
ISSN :
1522-4880
Print_ISBN :
978-1-4673-2534-9
Electronic_ISBN :
1522-4880
Type :
conf
DOI :
10.1109/ICIP.2012.6467489
Filename :
6467489
Link To Document :
بازگشت