In silico analyses of 24 human imprinted genes associated to diabesin triad (diabetes, obesity and inflammation): In search for a potential diabesin risk haplotype

Author

Bezerra, A.P.M. ; Silva-Santiago, Samara C. ; Oliveira, D.M. ; Vasconcelos, E.J.R. ; Silva, Margarida M. ; Pacheco, A.C.L.

Author_Institution

Programa de Pos-Grad. em Biotecnologia - RENORBIO, Univ. Estadual do Ceara - UECE, Fortaleza, Brazil

fYear

2012

fDate

4-7 Oct. 2012

Firstpage

956

Lastpage

958

Abstract

"Diabesin" is a term to describe concomitant morbid conditions of diabetes, obesity, and inflammation. Here we have performed in silico analyses of 24 (twenty four) human genes, known to undergo genomie imprinting, in order to choose potential genetic variants that might be associated to diabesin susceptibility. Our preliminary results indicate that potential diabesin risk haplotypes are a promising feature to be further investigated.

Keywords

diseases; genetics; genomics; concomitant morbid conditions; diabesin risk haplotypes; diabesin susceptibility; diabesin triad; diabetes; genetic variants; genomic imprinting; human imprinted genes; in silico analysis; inflammation; obesity; Bioinformatics; Diabetes; Genomics; Humans; Obesity; Proteins; diabesin; diabetes; genomie imprinting; in silico analyses; inflammation; obesity;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedicine Workshops (BIBMW), 2012 IEEE International Conference on

Conference_Location

Philadelphia, PA

Print_ISBN

978-1-4673-2746-6

Electronic_ISBN

978-1-4673-2744-2

Type

conf

DOI

10.1109/BIBMW.2012.6470281

Filename

6470281