DocumentCode
600895
Title
Pore dynamics induced by nsPEFs: A comparison between experimental and theoretical results
Author
Lamberti, Patrizia ; Romeo, Stefania ; Sannino, Anna ; Scarfi, Maria Rosaria ; Tucci, Vincenzo ; Zeni, Olga
Author_Institution
University of Salerno, Dept. of Electronic and Computer Engineering, Via Ponte Don Melillo - 84084 Fisciano (SA), Italy
fYear
2012
fDate
3-7 June 2012
Firstpage
524
Lastpage
527
Abstract
Starting from experimental data where plasma membrane permeabilization has been demonstrated in human lymphoblastoid Jurkat T-cells exposed to a single 60ns, 2.5 MV/m pulsed electric field, a 2D numerical model has been exploited in order to describe the dynamics of pore formation and induced transmembrane voltage. The adopted approach, employed here for the first time for nanosecond duration pulses, represents an useful tool to give insight into the involved physical phenomena and drive the experimental design in addressing mechanistic understanding and applications.
Keywords
Electroporation; FEM modeling; cell membrane; nsPEFs; pore density;
fLanguage
English
Publisher
ieee
Conference_Titel
Power Modulator and High Voltage Conference (IPMHVC), 2012 IEEE International
Conference_Location
San Diego, CA, USA
Print_ISBN
978-1-4673-1222-6
Type
conf
DOI
10.1109/IPMHVC.2012.6518796
Filename
6518796
Link To Document